2024
METTL17 is an Fe-S Cluster Checkpoint for Mitochondrial Translation
Ast, T.; Itoh, Y.; Sadra, S.; McCoy, J. G.; Namkoong, G.; Wengrod, J. C.; Chicherin, I.; Joshi, P. R.; Kamenski, P.; Suess, D. L. M.; Amunts, A.; Mootha, V. K.*
Mol. Cell, 84, 359-374.e8 (2024). DOI: 10.1016/j.molcell.2023.12.016
[Paper (PDF)] [Supporting Information (PDF)]
2023
An Iron-Sulfur Cluster with a Highly Pyramidalized Three-Coordinate Iron Center and a Negligible Affinity for Dinitrogen
Brown, A. C.; Suess, D. L. M.*
J. Am. Chem. Soc., 145, 20088-20096 (2023). DOI: 10.1021/jacs.3c07677
[Paper (PDF)] [Supporting Information (PDF)]
Cluster-Selective 57Fe Labeling of a Twitch-Domain-Containing Radical SAM Enzyme
Namkoong, G.; Suess, D. L. M.*
Chem. Sci., 14, 9492-9499 (2023). DOI: 10.1039/D3SC02016A
[Paper (PDF)] [Supporting Information (PDF)]
Exploiting Molecular Symmetry to Quantitatively Map the Excited State Landscape of Iron–Sulfur Clusters
Skeel, B. A.; Suess, D. L. M.*
J. Am. Chem. Soc., 145, 10376-10395 (2023). DOI: 10.1021/jacs.3c02412
[Paper (PDF)] [Supporting Information (PDF)]
A General Method for Metallocluster Site-Differentiation
Bostelaar, T. M.; Brown, A. C.; Sridharan, A; Suess, D. L. M.*
Nat. Synth., 2, 740-748 (2023). DOI: 10.1038/s44160-023-00286-7
[Paper (PDF)] [Supporting Information (PDF)]
Connecting the Geometric and Electronic Structures of the Nitrogenase Iron-Molybdenum Cofactor through Site-Selective 57Fe Labeling
Badding, E. D.; Srisantitham, S.; Lukoyanov, D.; Hoffman, B. M.; Suess, D. L. M.*
Nat. Chem., 15, 658-665 (2023). DOI: 10.1038/s41557-023-01154-9
[Paper (PDF)] [Supporting Information (PDF)]
An Open-Cuboidal [Fe3S4] Cluster Characterized in Both Biologically Relevant Redox States
Brown, A. C.; Suess, D. L. M.*
J. Am. Chem. Soc., 145, 2075-2080 (2023). DOI: 10.1021/jacs.2c13126
[Paper (PDF)] [Supporting Information (PDF)]
Facile and Dynamic Cleavage of Every Iron–Sulfide Bond in Cuboidal Iron–Sulfur Clusters
Thompson, N. B.; Namkoong, G.; Skeel, B. A.; Suess, D. L. M.*
Proc. Natl. Acad. Sci. U.S.A., 120, e2210528120 (2023). DOI: 10.1073/pnas.2210528120
[Paper (PDF)] [Supporting Information (PDF)]
Valence Localization in Alkyne and Alkene Adducts of Synthetic [Fe4S4]+ Clusters
Brown, A. C.; Suess, D. L. M.*
Inorg. Chem. (invited Forum Article), 62, 1911-1918 (2023). DOI: 10.1021/acs.inorgchem.2c01353
[Paper (PDF)] [Supporting Information (PDF)]
2022
The Elusive Mononitrosylated [Fe4S4] Cluster in Three Redox States
Kim, Y.; Sridharan, A.; Suess, D. L. M.*
Angew. Chem. Int. Ed., 134, e202213032 (2022). DOI: 10.1021/anie.202213032
[Paper (PDF)] [Supporting Information (PDF)]
Characterization by ENDOR Spectroscopy of the Iron-Alkyl Bond in a Synthetic Counterpart of Organometallic Intermediates in Radical SAM Enzymes
Ho, M. B.; Jodts, R. J.; Kim, Y.; McSkimming, A.; Suess, D. L. M.*; Hoffman, B. M.*
J. Am. Chem. Soc., 144, 17642-17650 (2022). DOI: 10.1021/jacs.2c07155
[Paper (PDF)] [Supporting Information (PDF)]
Reversible Alkyl-Group Migration between Iron and Sulfur in [Fe4S4] Clusters
Ye, M.; Brown, A. C.; Suess, D. L. M.*
J. Am. Chem. Soc., 144, 13184–13195 (2022). DOI: 10.1021/jacs.2c03195
[Paper (PDF)] [Supporting Information (PDF)]
Evidence for Low-Valent Electronic Configurations in Iron-Sulfur Clusters
Brown, A. C.; Thompson, N. B.; Suess, D. L. M.*
J. Am. Chem. Soc., 144, 9066–9073 (2022). DOI: 10.1021/jacs.2c01872
[Paper (PDF)] [Supporting Information (PDF)]
2021
Dinitrogen Binding and Activation at a Molybdenum–Iron–Sulfur Cluster
McSkimming, A.; Suess, D. L. M.*
Nat. Chem. 13, 666-670 (2021). DOI: 10.1038/s41557-021-00701-6
[Paper (PDF)] [Supporting Information (PDF)]
A Terminal Imido Complex of an Iron–Sulfur Cluster
Sridharan, A.; Brown, A. C.; Suess, D. L. M.*
Angew. Chem. Int. Ed. 60, 12802–12806 (2021). DOI: 10.1002/anie.202102603
[Paper (PDF)] [Supporting Information (PDF)]
Synthetic Iron–Sulfur Clusters
Brown, A. C.; Suess, D. L. M.*
Book chapter in Comprehensive Coordination Chemistry III, Vol. 8; Constable, E. C., Parkin, G., Que, L., Eds.; Elsevier, Amsterdam, 2021; pp 134–156. DOI: 10.1016/B978-0-08-102688-5.00053-2
Postbiosynthetic Modification of a Precursor to the Nitrogenase Iron–Molybdenum Cofactor
Srisantitham, S.; Badding, E. D; Suess, D. L. M.*
Proc. Natl. Acad. Sci. U.S.A. 118, e2015361118 (2021). DOI: 10.1021/pnas.2015361118
[Paper (PDF)] [Supporting Information (PDF)]
2020
Reversible Formation of Alkyl Radicals at [Fe4S4] Clusters and Its Implications for Selectivity in Radical SAM Enzymes
Brown, A. C.; Suess, D. L. M.*
J. Am. Chem. Soc. 142, 14240–14248 (2020). DOI: 10.1021/jacs.0c05590
[Paper (PDF)] [Supporting Information (PDF)]
An [Fe4S4]3+–Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand
McSkimming, A.; Sridharan, A.; Thompson, N. B.; Müller, P.; Suess, D. L. M.*
J. Am. Chem. Soc. 142, 14314–14323 (2020). DOI: 10.1021/jacs.0c06334
[Paper (PDF)] [Supporting Information (PDF)]
2019
A Synthetic Model of Enzymatic [Fe4S4]–Alkyl Intermediates
Ye, M.; Thompson, N. B.; Brown, A. C.; Suess, D. L. M.*
J. Am. Chem. Soc. 141, 13330–13335 (2019). DOI: 10.1021/jacs.9b06975
[Paper (PDF)] [Supporting Information (PDF)]
Controlling Substrate Binding to Fe4S4 Clusters Through Remote Steric Effects
Brown, A. C.; Suess, D. L. M.*
Inorg. Chem. 58, 5273–5280 (2019). DOI: 10.1021/acs.inorgchem.9b00360
[Paper (PDF)] [Supporting Information (PDF)]
2018
Selective Synthesis of Site-Differentiated Fe4S4 and Fe6S6 Clusters
McSkimming, A.; Suess, D. L. M.*
Inorg. Chem. 57, 14904–14912 (2018). DOI: 10.1021/acs.inorgchem.8b02684
[Paper (PDF)] [Supporting Information (PDF)]
Publications from undergraduate, graduate, and postdoctoral studies
Rao, G.; Tau, L.; Suess, D. L. M.; Britt, R. D.* A [4Fe–4S]-Fe(CO)(CN)-L-cysteine intermediate is the first organometallic precursor in [FeFe] hydrogenase H-cluster bioassembly. Nat. Chem. 10, 555–560 (2018). DOI: 10.1038/s41557-018-0026-7
Guo, Y.; Suess, D. L. M.; Herzik, M. A.; Iavarone, A. T.; Britt, R. D.; Marletta, M. A. Regulation of nitric oxide signaling by formation of a distal receptor–ligand complex. Nat. Chem. Biol. 13, 1216–1221 (2017). DOI: 10.1038/nchembio.2488
Nguyen, A. I.; Suess, D. L. M.; Darago, L. E.; Oyala, P. H.; Levine, D. S.; Ziegler, M. S.; Britt, R. D.*; Tilley, T. D.* Manganese–Cobalt Oxido Cubanes Relevant to Manganese-Doped Water Oxidation Catalysts. J. Am. Chem. Soc. 139, 5579–5587 (2017). DOI: 10.1021/jacs.7b01792
Span, E. A.; Suess, D. L. M.; Deller, M. C.; Britt, R. D.; Marletta, M. A.* The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase. ACS Chem. Biol. 12, 1095–1103 (2017). DOI: 10.1021/acschembio.7b00016
Suess, D. L. M.; Pham, C. C.; Bürstel, I.; Swartz, J. R.; Cramer, S. P.*; Britt, R. D.* The Radical SAM Enzyme HydG Requires Cysteine and a Dangler Iron for Generating an Organometallic Precursor to the [FeFe]-Hydrogenase H-Cluster. J. Am. Chem. Soc. 138, 1146–1149 (2016). DOI: 10.1021/jacs.5b12512
Suess, D. L. M.; Kuchenreuther, J. M.; De La Paz, L.; Swartz, J. R.; Britt, R. D.* Biosynthesis of the [FeFe] Hydrogenase H Cluster: A Central Role for the Radical SAM Enzyme HydG. Inorg. Chem. 55, 478–487 (2016). DOI: 10.1021/acs.inorgchem.5b02274
Richardson, D. P.*; Bauer, G. S.; Bravo, A. A.; Drzyzga, M.; Motazedi, T.; Pelegri-O’Day, E. M.; Poudyal, S.; Suess, D. L. M.; Thoman, J. W. A convenient and practical method for the selective preparation of deuterofluorocarbons. J. Fluor. Chem. 180, 208–215 (2015). DOI: 10.1016/j.jfluchem.2015.10.002
Nesbit, M. A.; Suess, D. L. M.; Peters, J. C.* E–H Bond Activations and Hydrosilylation Catalysis with Iron and Cobalt Metalloboranes. Organometallics 34, 4741–4752 (2015). DOI: 10.1021/acs.organomet.5b00530
Del Castillo, T. J.; Thompson, N. B.; Suess, D. L. M.; Ung, G.; Peters, J. C.* Evaluating Molecular Cobalt Complexes for the Conversion of N2 to NH3. Inorg. Chem. 54, 9256–9262 (2015). DOI: 10.1021/acs.inorgchem.5b00645
Suess, D. L. M.; Bürstel, I.; De La Paz, L.; Kuchenreuther, J. M.; Pham, C. C.; Cramer, S. P.; Swartz, J. R.; Britt, R. D.* Cysteine as a ligand platform in the biosynthesis of the FeFe hydrogenase H cluster. Proc. Natl. Acad. Sci. 112, 11455–11460 (2015). DOI: 10.1073/pnas.1508440112
Suess, D. L. M.; Britt, R. D.* EPR Spectroscopic Studies of [FeFe]-Hydrogenase Maturation. Top. Catal. 58, 699–707 (2015). DOI: 10.1007/s11244-015-0412-y
Britt, R. D.*; Suess, D. L. M.; Stich, T. A. An Mn(V)-oxo role in splitting water? Proc. Natl. Acad. Sci. 112, 5265–5266 (2015). DOI: 10.1073/pnas.1505223112
Dinis, P.; Suess, D. L. M.; Fox, S. J.; Harmer, J. E.; Driesener, R. C.; De La Paz, L.; Swartz, J. R.; Essex, J. W.; Britt, R. D.; Roach, P. L.* X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly. Proc. Natl. Acad. Sci. 112, 1362–1367 (2015). DOI: 10.1073/pnas.1417252112
Gunderson, W. A.; Suess, D. L. M.; Fong, H.; Wang, X.; Hoffmann, C. M.; Cutsail III, G. E.; Peters, J. C.*; Hoffman, B. M.* Free H2 Rotation vs. Jahn–Teller Constraints in the Nonclassical Trigonal (TPB)Co–H2 Complex. J. Am. Chem. Soc. 136, 14998–15009 (2014). DOI: 10.1021/ja508117h
Myers, W. K.; Stich, T. A.; Suess, D. L. M.; Kuchenreuther, J. M.; Swartz, J. R.; Britt, R. D.* The Cyanide Ligands of [FeFe] Hydrogenase: Pulse EPR Studies of 13C and 15N-Labeled H-Cluster. J. Am. Chem. Soc. 136, 12237–12240 (2014). DOI: 10.1021/ja507046w
Kuchenreuther, J. M.; Myers, W. K.; Suess, D. L. M.; Stich, T. A.; Pelmenschikov, V.; Shiigi, S. A.; Cramer, S. P.; Swartz, J. R.; Britt, R. D.*; George, S. J.* The HydG enzyme generates an Fe(CO)2(CN) synthon in assembly of the FeFe hydrogenase H-cluster. Science 343, 424–427 (2014). DOI: 10.1126/science.1246572
Suess, D. L. M.; Peters, J. C.* A CO-Derived Iron Dicarbyne That Releases Olefin upon Hydrogenation. J. Am. Chem. Soc. 135, 12580–12583 (2013). DOI: 10.1021/ja406874k
Suess, D. L. M.; Peters, J. C.* H–H and Si–H Bond Addition to Fe≡NNR2 Intermediates Derived from N2. J. Am. Chem. Soc. 135, 4938–4941 (2013). DOI: 10.1021/ja400836u
Suess, D. L. M.; Tsay, C.; Peters, J. C.* Dihydrogen Binding to Isostructural S = ½ and S = 0 Cobalt Complexes. J. Am. Chem. Soc. 134, 14158–14164 (2012). DOI: 10.1021/ja305248f
Suess, D. L. M.; Peters, J. C.* Late-Metal Diphosphinosulfinyl S(O)P2 Pincer-type Complexes. Organometallics 31, 5213–5222 (2012). DOI: 10.1021/om3001229
Suess, D. L. M.; Peters, J. C.* Ligand design for site-selective installation of Pd and Pt centers to generate homo- and heteropolymetallic motifs. Chem. Commun. 46, 6554–6556 (2010). DOI: 10.1039/c003163a